Baptised in October 1620 in Dordrecht, son of the painter J. G. Cuyp (1594-1652) under whom he first studied, and nephew of the painter Benjamin Cuyp (1612-50).
His earliest landscapes (from 1639) were influenced by van Goyen, but he later discovered the Italianate views of the Utrecht painters Jan Both, and Saftleven.
Though he travelled up the Rhine in 1651 or 1652, he seems rarely to have left Dordrecht and his work remained little known outside the town until the eighteenth century. Following the deaths of his father and uncle, his work assumed a somewhat grander character, to include equestrian portraits and extensive views, but it appears he painted very little after his marriage to a wealthy widow in 1658. He was buried on 15 November 1691.