Domenico Zampieri, called Domenichino, was born in October 1581 in Bologna where he first studied under Denis Calvaert before entering the Carracci Academy in, or after, 1595. In 1602 he went to Rome where be assisted Annibale Carracci in the decoration of the Galleria Farnese (1603-5). In 1612 he received two important commissions: the S. Cecilia frescoes in S. Luigi dei Francesi (1612-5), and an altarpiece for S. Girolamo della Carità (The Last Communion of S. Jerome, 1614).
In 1617 he returned to Bologna, but with the election of a Bolognese Pope, Gregory XV, in 1621, Domenichino returned to Rome where he was made Papal Architect and received an increasing number of commissions, notably for the decoration of the New Theatine church of S. Andrea della Valle (1622-7). In 1631 he undertook to supply frescoes and five altarpieces for the Duomo at Naples and, apart from a visit to Rome in 1634-5, this commission occupied him until his death in Naples on 6 April 1641.