Born in Leiden on 3 June 1662, younger brother of Jan and the son of Frans van Mieris the elder, under whom he trained. He entered the Leiden guild in 1683 and served as dean in 1699. In 1694 he was one of three painters who set up a drawing academy in Leiden; he was co-director with Karel de Moor until 1736. His style, dependent on that of his father, continued the tradition of the Leiden 'fine painters'.
He painted both genre and history subjects as well as portraits and is recorded designing and modelling relief decoration on garden vases. He spent his entire life at Leiden where he died on 26 January 1747.